EPI: Enabling Personalized Interventions.

https://mns-research.nl/ https://cci-research.nl/ http://uva.nl/
The EPI project is funded by the Dutch Science Foundation
in the Commit2Data program (grant no: 628.011.028)


Knowledge is power -- and in healthcare, that holds absolutely true. Yet, for an industry that is under financial stress, increasing complexity of disease and co-morbidity, and burdened by capacity constraints -- why has data not been health care's savvier? Three major challenges have inhibited this:

  1. data is not accessible and remains in silos;
  2. data is not analysed to derive meaningful clinical insights;
  3. insight isn't accessible for actioning by providers or patients to self/joint manage their condition.

Our consortium of medical professionals, data scientists, IT-infrastructure experts, machine learning researchers and legal experts have designed Enabling Patient Interventions to liberate, analyse, and action that data in a trustworthy way. EPI aims to empower patients and providers through self-management, shared management, and personalization across the full health spectrum. To do so, we will build a fuller picture of the person by linking traditional eHealth data sets with new sources of data. Further, we will develop a platform based upon a secure and trustworthy distributed data infrastructure, combining data analytics, including machine learning, and health decision support algorithms to create new, actionable, and personalized insights for prevention, management, and intervention to providers and patients. We will develop new machine learning methods for determining and analysing optimal interventions within small patient groups.
Our insights will be applied in healthcare use cases representing a spectrum of health management challenges ranging from common chronic to highly lethal orphan diseases, and will empower better self/joint management of these conditions to improve cost, quality, and outcomes of care.

Here are introductory slides about the project: in Dutch, and in English. This website is reachable under: https://enablingpersonalizedinterventions.nl/

Research topics:

The overall aim of this project is to explore the use and effectiveness of data driven development of scientific algorithms, supporting personalized self- and joint management during medical interventions / treatments. The key objective is to use data science promoting health practically with data from various sources to formulate lifestyle advice, prevention, diagnostics, and treatment tailored to the individual, and to provide personalized, effective, real-time feedback via a concept referred in this proposal as a digital health twin. The project addresses six research questions:

  • RQ1/2:
    • Dynamically Analyzing Interventions based on Small Groups: how can we determine, based on as little data as possible, whether an intervention does or does not work for a small group or even an individual patient? And how can we identify effective intervention strategies and optimize personalization strategies applicable for different patient and lifestyle profiles via dynamic (on-line) clustering of patients?
    • Lead CWI: Rosanne Turner, Peter Grunwald
  • RQ3:
    • Data and Algorithm Distribution: what are the consequences of a distributed, multi-platform, multi-domain, multi-data-source big data infrastructure on the machine learning algorithms and what are potential consequences on performance?
    • Lead: VU, Corinne Allaart, Henri Bal
  • RQ4:
    • Adaptive health diagnosis leading to optimized intervention: how can we enhance self- / joint management by dynamically integrating updated models generated from machine learning from various data sources in state of the art health support systems that based on personal health records, knowledge of health modes and effective interventions?
    • Lead: UvA, Saba Amiri, Adam Belloum
  • RQ5:
    • Regulatory constraints and data governance: how can we create scalable solutions that meet legal requirements and consent or medical necessity-based access to data for allowed data processing and preventing breaches of these rules by embedded compliance, providing evidence trails and transparency, thus building trust in a sensitive big data sharing infrastructure?
    • Lead: UvA, Milen Girma Kebede, Giovanni Sileno, Tom van Engers
  • RQ6:
    • Infrastructure: how can the various requirements from the use-cases be implemented using a single functional ICT-infrastructure architecture?
    • Lead: UvA, Jamila Kassem, Paola Grosso



  1. Leon Gommans, John Vollbrecht, Betty Gommans - de Bruijn, Cees de Laat, "The Service Provider Group Framework; A framework for arranging trust and power to facilitate authorization of network services.", Future Generation Computer Systems, (Accepted paper), June 2014
  2. Leon Gommans, "Multi-Domain Authorization for e-Infrastructures", UvA, Dec 2014.
  3. Internet2 2012 session: "Trust Framework for Multi-Domain Authorization".
    • speakers: Leon Gommans , John Vollbrecht, chair:  Cees de Laat.
  4. Managing Our Hub Economy, Marco Iansiti, Karim R. Lakhani, Harvard Business review, September-October 2017 issue, [local copy]
  5. NWO press release: Enabling Personalized Interventions - EPI.


2024-03-07 EPI Closing Conference

Presentations at the EPI Quarterly meeting on January 17, 2024.

B Borsos, CG Allaart, A van Halteren. Predicting stroke outcome: A case for multimodal deep learning methods with tabular and CT Perfusion data. 2024 Artificial Intelligence in Medicine 147, 102719 https://www.sciencedirect.com/science/article/pii/S0933365723002336

PhD thesis defense in the Academiegebouw of Leiden University, promotor prof.dr. Peter D. Grunwald: Rosanne J. Turner, "Safe Anytime-Valid Inference: From Theory to Implementation in Psychiatry Research."

2023-08-31 Paper: Yuri van der Does, Rosanne J. Turner, Miel J.H. Bartels, Karin Hagoort, Aäron Metselaar, Floortje Scheepers, Peter D. Grünwald, Metten Somers and Edwin van Dellen. “Outcome prediction of electroconvulsive therapy for depression”. Published in Psychiatry Research Volume 326, August 2023, 115328. Link to full text: https://doi.org/10.1016/j.psychres.2023.115328

2023-05-24 Paper: Rosanne J Turner, Karin Hagoort, Rosa J Meijer, Femke Coenen and Floortje E Scheepers: “Bayesian network analysis of antidepressant treatment trajectories”. Published in Scientific reports 2023 May 24;13(1):8428. Link to full text: https://www.nature.com/articles/s41598-023-35508-7

2023-04-26 Paper: accepted for presentation at AISTATS 2023 and published in proceedings Rosanne J. Turner and Peter D. Grunwald "Safe Sequential Testing and Effect Estimation in Stratified Count Data", gepubliceerd in PMLR 206, 2023. https://proceedings.mlr.press/v206/turner23a/turner23a.pdf

2023-04-20 Tutorial by Tim Müller and Adam Belloum "Introduction to the EPI Framework", at ICT.OPEN 2023 in Utrecht (NL).

Presentations at the EPI Quarterly meeting on November 8, 2022.

2022-10-12 J. A. Kassem, A. Belloum, T. Müller and P. Grosso, "Utilisation Profiles of Bridging Function Chain for Healthcare Use Cases," 2022 IEEE 18th International Conference on e-Science (e-Science), Salt Lake City, UT, USA, 2022, pp. 475-480, doi: 10.1109/eScience55777.2022.00085.

2022-10-11 C. A. Esterhuyse, T. Müller, L. T. Van Binsbergen and A. S. Z. Belloum, "Exploring the Enforcement of Private, Dynamic Policies on Medical Workflow Execution," 2022 IEEE 18th International Conference on e-Science (e-Science), Salt Lake City, UT, USA, 2022, pp. 481-486, doi: 10.1109/eScience55777.2022.00086.

Paper:  "CG Allaart, B Keyser, H Bal, A Van Halteren. Vertical Split Learning-an exploration of predictive performance in medical and other use cases. 2022 International Joint Conference on Neural Networks (IJCNN), 1-8", https://ieeexplore.ieee.org/abstract/document/9891964

R.J. Turner "Sequential Tests with Optional Stopping and Anytime-Valid Effect Size Estimation for Two-Sample Data Streams using E-Processes", Presented at the IMS Annual Meeting 2022.

2022-06-21 Short paper: R.J. Turner (Rosanne), P.D. Grünwald (Peter) and A. Härmä (Aki) "Safe Sequential Conditional Independence Tests for Discrete Variables" Presented at the OCUPAI'22 - Online Conference to Unite Philips AI 2022 (June 2022), Online.

R.J. Turner (Rosanne), F. Coenen (Femke), F. Roelofs (Femke), K. Hagoort (Karin), A. Härmä (Aki), P.D. Grünwald (Peter), F.P. Velders (Fleur) and F.E. Scheepers (Floortje) "Information extraction from free text for aiding transdiagnostic psychiatry: constructing NLP pipelines tailored to clinicians’ needs" BMC Psychiatry, 2022, Volume 22 p. 407.1- 407.11.c

Presentation: R.J. Turner "Anytime-valid Confidence Intervals for Contingency Tables and Beyond", Presented at the workshop Save Anytime-Valid Inference and Game-theoretic Statistics, 2022.

Presentation: R.J. Turner and P.D. Grünwald "Anytime-valid testing and confidence intervals in contingency tables and beyond", Presented at the A/B Testing Workshop (May 2022), Amsterdam, the Netherlands.

Presentation: R.J. Turner "Netwerkanalyse van antidepressiva behandeltrajecten", Presented at the NVVP (Dutch Psychiatry Association) Spring Conference , May 11-13, 2022.

2022-04-07 Presentations and posters ICT.OPEN in the RAI Amsterdam: Enabling Personalized Interventions (EPI) Consortium Meeting and contributions at ICT.Open

2022-03-23 Paper: Rosanne J. Turner and Peter D. Grunwald "Exact Anytime-valid Confidence Intervals for Contingency Tables and Beyond" in Statistics & Probability Letters, 109835. 2023. https://doi.org/10.1016/j.spl.2023.109835

2022-03-02 At SC-Asia in the Asia Pacific Research Platform (APRP) session chaired by mr. Yves Poppe (NSCC): "Secure data sharing in the Responsible Internet.".

Presentations at the EPI Quarterly meeting on January 17, 2022.

2022-01-16 Presentation: L. Thomas van Binsbergen. at Programming Languages and the Law ProLaLa 2022. Reflections on the design and application of eFLINT. Programming Languages and the Law 2022, [youtube link].

2021-11-11 Interview: "SuperScience: Vertrouwd gevoelige data kunnen delen en verwerken", interview door Sjoerd Hartholt, Redacteur AG-Connect van Cees de Laat, AG-Connect - 11 Nov 2021

2021-11-01 Presentation and Paper: van Binsbergen, L. T., Kebede, M. G., Baugh, J., van Engers, T., & van Vuurden, D. G. Dynamic generation of access control policies from social policies, The 11th International Conference on Current and Future Trends of Information and Communication Technologies in Healthcare (ICTH 2021)November 1-4, 2021, Leuven, Belgium. https://ltvanbinsbergen.nl/files/papers/icth2021.pdf

2021-09-23 Presentation and paper by Onno Valkering at 17th IEEE eScience 2021, International Conference ReWorDS21 workshop:  "Brane: A Framework for Programmable Orchestration of Multi-site Applications."

2021-09-22 Presentation and paper by Jamila Alsayed Kassem at 17th IEEE eScience 2021, International Conference:  "EPI Framework: Approach for Traffic Redirection Through Containerised Network Functions."

2021-08-27 Presentation by Thomas van Binsbergen at Communications of the ACM Europe Region Special Section Virtual Workshop (CACM), aug 25 - 26, 2021: "Digital Data Marketplaces".

Presentations at the EPI Quarterly meeting on July 1, 2021.

Paper: Rosanne Turner, Alexander Ly, Peter Grunwald, "Two-Sample Tests that are Safe under Optional Stopping, with an Application to Contingency Tables", Published on arXiv:2106.02693 [stat.ME].

2021-04-22 Presentations at the EPI April 22, 2021: Tiny Workshop & Consortium Meeting Enabling Personalized Interventions.

2021-02-11 Presentation and abstract at ICT-Open 2021 Feb 10-11, 2021: Jamila Alsayed Kassem, "EPI Framework: A dynamic infrastructure to support health applications."

Paper: Kebede M.G. (2021) Automating Normative Control for Healthcare Research. In: Rodríguez-Doncel V., Palmirani M., Araszkiewicz M., Casanovas P., Pagallo U., Sartor G. (eds) AI Approaches to the Complexity of Legal Systems XI-XII. AICOL 2020, AICOL 2018, XAILA 2020. Lecture Notes in Computer Science, vol 13048. Springer, Cham. https://doi.org/10.1007/978-3-030-89811-3_5

2020-12-09 Paper: Kebede M.G., Sileno G., Van Engers T. (2021) A Critical Reflection on ODRL. In: Rodríguez-Doncel V., Palmirani M., Araszkiewicz M., Casanovas P., Pagallo U., Sartor G. (eds) AI Approaches to the Complexity of Legal Systems XI-XII. AICOL 2020, AICOL 2018, XAILA 2020. Lecture Notes in Computer Science, vol 13048. Springer, Cham. https://doi.org/10.1007/978-3-030-89811-3_4

2020-11-09 Short Paper: R.J. Turner and P.D. Grünwald. "Safe Tests for 2 x 2 Contingency Tables and the Cochran-Mantel-Haenszel Test" presentation at BNAIC/ BENELEARN 2020.

2020-09-24 Paper: Jamila Alsayed Kassem, Cees de Laat, Arie Taal, and Paola Grosso, The EPI Framework: A dynamic data sharing framework for healthcare use cases",  IEEE Acees journal, Digital Object Identifier  DOI 10.1109/ACCESS.2020.3028051

2020-08-09 Paper: Wouter van Haaften, Alex Sangers, Tom van Engers, Somayeh Djafari, "Coping with the general data protection regulation: Anonymization through multi-party computation technology.", IRIS/SCIS Conference, 9-12 August 2020, Sundsvall, Sweden, <https://www.irisscis2020.com>

2020-06-29 Rosanne J. Turner, "Safe Statistics for Means and Proportions", video presentation at the Machine Learning Summer School 2020 by the Max Planck Institute for Intelligent Systems, Tübingen, Germany. Link to the video: https://youtu.be/H5RMtnydAQI

2020-04-22 Presentation at the EPI-PHD online quarterly meeting: Freek Dijkstra, "Data Exchange Demo: Share data while retaining control and confidentiality of your data."

2020-04-22 Presentation at the EPI-PHD online quarterly meeting: Guido van 't Noordende, "Push authorization - the Whitebox model."

2020-03-17 Poster and short paper at ICT.OPEN 2020 (cancelled): Rosanne J. Turner, Alexander Ly, Judith ter Schure, Peter D. Grünwald , "Safe Testing: online, anytime valid hypothesis tests.  "

2020-03-17 Poster and short paper at ICT.OPEN 2020 (cancelled): Jamila Alsayed Kassem, "EPI infrastructure: A dynamic infrastructure to secure data sharing in healthcare applications."

2020-03-17 Poster and short paper at ICT.OPEN 2020 (cancelled): Milen G. Kebede, Giovanni Sileno, Tom Van Engers, "Automated regulatory constraints and data governance for healthcare,"

2019-10-31 Poster at NWO COMMIT2DATA PI meeting, Utrecht: "Enabling Personalized Interventions (EPI)."

2019-10-11 Presentation by Cees de Laat: Department of Computer Science, AGH University of Science and Technology Krakow: "ICT to support the transformation of Science in the Roaring Twenties."

2019-10-02 Poster by Corrine Allaart (VU) at Big Data Health and Data2Person event, Amersfoort: " Distributed Deep Learning voor Cerebrovascular Accident."

2019-10-02 Presentation Pitch by Corinne Allaart (VU) at Big Data Health and Data2Person event, Amersfoort: " Distributed Deep Learning voor Cerebrovascular Accident."

2019-09-25 Presentation by Cees de Laat: eScience conference Visionary track, San Diego: "ICT to support the transformation of Science in the Roaring Twenties."

2019-08-22 Presentation by Cees de Laat: CIENA executive briefing invited science presentation, Ottawa: "ICT to support the transformation of Science in the Roaring Twenties."

2019-09-18 Presentation by Cees de Laat: Global Research Platform (GRP) workshop, San Diego: "Globally Distributed Secure Data Exchange Fabrics."

2019-04-25 Presentation by Cees de Laat, Sander Klous, Josine Janus at kick off meeting: "Enabling personalized Intervetions".

2018-12-18 SURFSARA Superdag 2018 talk: "Digital Data Markets: Trusted Data Processing in Untrusted Environments".

2018-05-09 Session organized by Cees de Laat (chair) at Internet2 Summit, Washington, May 9, 2018; "Digital Marketplaces Using Novel Infrastructure Models."

2017-02-24 Report from NWO/STW Workshop "ICT with Industry 2016" Lorenz Centre Leiden, Nov. 7-11th 2016; Prof. dr. Tom M. van Engers (UvA), Prof. dr. Robert Meijer (UvA, TNO), Dr. ing. Leon Gommans (Air France KLM Group ICT Technology Office R&D, UvA), Dr. Kees Nieuwenhuis (Thales Nederland B.V., CTO Office), "Trusted Big Data Sharing for Aircraft MRO using a Secure Digital Market Place mechanism."